Agustini, Agustini (2019) PENGARUH PEMBERIAN EKSTRAK ETANOL BIJI ADAS (Foeniculum vulgare, Mill) terhadap PERSENTASE LIMFOSIT, GAMBARAN HISTOPATOLOGI LIMPA dan USUS pada MENCIT Balb/C yang TERPAPAR BAKTERI Salmonella typhi. Skripsi thesis, Universitas Setia Budi.
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Abstract
Fennel seeds (Foeniculum vulgare, Mill) contain flavonoids, saponins, tannins and essential oils. The content of fennel seed compounds can potentially be an immunostimulant. Flavonoids are potential to increase lymphocyte proliferation activity, saponins can increase lymphocyte activity, and essential oils can be antimicrobial pathogenic bacteria. The objective of this research was find out the effect of fennel seed extract (Foeniculum vulgare, Mill) on the percentage of lymphocytes, histopathological features of the spleen and small intestine of Balb/C mouse infected by Salmonella typhi bacteria. This research used an experimental method with a post test only control group design in vivo. Fennel seed extract was obtained by conducting sokhletation process. This research used 30 Balb/C mice, which were divided into 5 groups and each group consisted of 6 mice. Group I was given 0.5% CMC, group II was induced by Salmonella typhi bacteria. The IIIV treatment group was given fennel seed extract (Foeniculum vulgare, Mill) with varying doses of 250, 500, and 750 mg/kg body weight. The results of the research how that the ethanol extract of fennel seeds (Foeniculum vulgare, Mill) influences the percentage of lymphocytes with an effective dose of 750 mg/kg body weight compared to doses of 250 and 500 mg/kg body weight. Histopathological observation shows that fennel seed extract is relatively influential in improving the histopathological picture of Balb/C mice’s spleen that were induced by Salmonella typhi and relatively influential in improving the histopathological picture of Balb/C mice’s small intestine. However, the improvement is not maximal on day 28. Keywords: Lymphocytes percentage, fennel seed extract, histopathology, spleen, small intestine.
| Item Type: | Thesis (Skripsi) |
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| Additional Information: | Dra. Dewi Sulistyawati, M.Sc. ; Ifandari, S.Si.,M.Si. |
| Uncontrolled Keywords: | Lymphocytes percentage, fennel seed extract, histopathology, spleen, small intestine |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Ilmu Kesehatan > Prodi D4 Analis Kesehatan |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 11 Oct 2019 03:08 |
| Last Modified: | 11 Oct 2019 03:08 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/3207 |
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