PENGARUH EKTRAK DAUN MANGGA KASTURI (Mangifera casturi Koesterm) TERHADAP KADAR TRIGLISERIDA PADA TIKUS PUTIH JANTAN GALUR WISTAR HIPERLIPIDEMIA

Wafa, Ahmad Syahibul (2019) PENGARUH EKTRAK DAUN MANGGA KASTURI (Mangifera casturi Koesterm) TERHADAP KADAR TRIGLISERIDA PADA TIKUS PUTIH JANTAN GALUR WISTAR HIPERLIPIDEMIA. Skripsi thesis, Universitas Setia Budi.

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Abstract

Kasturi mango leaves are one of medicinal plants that contain flavonoids, saponins and tannins which can act as a decrease of triglyceride levels in blood. The aim of this study was to determine the effect of the administration of kasturi mango leaves extract on triglyceride levels of hyperlipidemic wistar strain white rats induced by high fat diet and propylthiouracil. The study was carried out for 21 days using 30 rats divided into 6 groups: normal group, negative group (CMC 0.5%) positive group (gemfibrozil 10.8 mg / 200 g BB), dose of mango kasturi leaf ethanol extract was 100 mg / kg BW , 200 mg / kg BW, 400 mg / kgBW. All groups except the normal group were given an induction of a high-fat diet and propylthiouracil for 14 days. Measurements of triglyceride levels were carried out on the 0th, 14th and 21st days using the GPO-PAP method. The test results were analyzed statistically using One Way Anova. The results showed that the extract of mango kasturi leaves at a dose of 100 mg / kg body weight, 200 mg / kg body weight, 400 mg / kg body weight could reduce triglyceride levels, the percentage results were 43.29%, 56.97%, 84.11% . The best percentage reduction was shown at a dose of 400 mg / kg body weight (84.11%) because it was equivalent to the percentage decrease in gemfibrozil (92.71%). From the three dosage variations, it can be concluded that the extract of kasturi mango leaves has an effect on decreasing triglyceride levels and the effective dose is 400 mg / kg BW. Key words : extract of kasturi mango leaf, high-fat diet, propylthiouracil, hiperlipidemic

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	extract of kasturi mango leaf, high-fat diet, propylthiouracil, hiperlipidemic
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	01 Nov 2019 03:40
Last Modified:	01 Nov 2019 03:40
URI:	http://repo.setiabudi.ac.id/id/eprint/3475

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