UJI SITOTOKSISITAS EKSTRAK ETANOL DAUN PUCUK MERAH (Syzygium myrtifolium Walp.) TERHADAP KULTUR SEL KANKER HATI HepG2

Winanto, Septian Abi (2019) UJI SITOTOKSISITAS EKSTRAK ETANOL DAUN PUCUK MERAH (Syzygium myrtifolium Walp.) TERHADAP KULTUR SEL KANKER HATI HepG2. Skripsi thesis, Universitas Setia Budi.

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Abstract

Liver cancer is a type of cancer that is increasingly in the world and especially in Indonesia. Red Tip (Syzygium myrtifolium Walp.) leaf contain antioxidant components such us flavonoids, tannins, and terpenoids so can be investigated to be used as an anticancer. This study aimed to determine the cytotoxic activity and selectivity of red tip leaf ethanol extract against liver cancer cell culture HepG2. This study included extraction of red tip leaf using maceration method with 70% ethanol. Cytotoxic test of red tip leaf ethanol extract was carried out by MTT assay method using concentration series (1000; 500; 250; 125; 62,5; 31,2; 15,6) µg/ml and IC50 values were calculated using linear regression. The selectivity index to determine cytotoxic selectivity is known by calculating between the IC50 values of Vero cells compared with the IC50 value of HepG2 cells. Cytotoxic test results of red tip leaf ethanol extract showed less potent activity on HepG2 cells with IC50 value 434,367 µg/ml, but had high cytotoxic selectivity with selectivity index value 3,53. Keywords : cytotoxic, HepG2, IC50, Syzygium myrtifolium Walp., Vero.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: cytotoxic, HepG2, IC50, Syzygium myrtifolium Walp., Vero.
Subjects: R Medicine > RC Internal medicine
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Tifany Nur Arfiana
Date Deposited: 15 Nov 2019 06:54
Last Modified: 15 Nov 2019 06:54
URI: http://repo.setiabudi.ac.id/id/eprint/3873

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