PENGARUH VARIASI KONSENTRASI GELLING AGENT HPMC K100M TERHADAP SIFAT FISIK DAN AKTIVITAS GEL ANTIOKSIDAN EKSTRAK KAYU SECANG (Caesalpinia sappan L.) DENGAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazyl)

Choirunnisa, Fitria (2018) PENGARUH VARIASI KONSENTRASI GELLING AGENT HPMC K100M TERHADAP SIFAT FISIK DAN AKTIVITAS GEL ANTIOKSIDAN EKSTRAK KAYU SECANG (Caesalpinia sappan L.) DENGAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazyl). Skripsi thesis, Universitas Setia Budi Surakarta.

	Text INTISARI-ABSTRACT.pdf Download (94kB)
	Text SKRIPSI FITRI.pdf Download (5MB)

Abstract

Sappan wood extract (Caesalpinia sappan L.) has very strong antioxidant activity cause its high flavonoid contains. Topical antioxidants prevent skin damage caused by free radicals. Gel is semi solid pharmaceutical dosage forms that used topically. One of the factors that influence physical properties of gel are gelling agent. The purpose of this study was to determine influence of gelling agent concentration HPMC K100M variation on physical properties and antioxidant gel activity. Gel was formulated into four formulas with variation of HPMC K100M 1%; 1.25%; 1.50%, and 1.75%. Formula 1 to 4 contains 0,2% of sappan wood extract, formula 5 (negative control), and formula 6 contains rutin (positive control). Tests of physical properties include organoleptic, homogeneity, dispersion, adhesion, pH, viscosity, and irritation test on respondents. Antioxidant activity was tested with DPPH (1,1-Diphenyl-2-Picrylhydrazyl), using UV-Vis spectrophotometer in 516 nm wavelength. The absorbance data used to measure IC50. The results of the data were analyzed using one-way ANOVA with 95% confidence level. The results showed increasing concentration of HPMC K100M caused increasing of viscosity and adhesion, decreased dispersion, but did not affect in homogeneity and pH gel. Irritation test to respondent showed that formula was safe for skin. Antioxidant test showed increasing concentration of HPMC K100M give IC50 in formula 1 to formula 4 have activity 11,594; 17,055; 21,669; and 27,191 ppm. Keywords: Caesalpinia sappan L., antioxidant, DPPH, HPMC

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Caesalpinia sappan L., antioxidant, DPPH, HPMC
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	23 Feb 2019 02:30
Last Modified:	23 Feb 2019 02:30
URI:	http://repo.setiabudi.ac.id/id/eprint/398

Actions (login required)

View Item