POTENSI EKSTRAK BIJI PEPAYA (Carica papaya L.) SEBAGAI ANTIOKSIDAN DALAM SEDIAAN GEL ANTIOKSIDAN

Martina, Prima (2020) POTENSI EKSTRAK BIJI PEPAYA (Carica papaya L.) SEBAGAI ANTIOKSIDAN DALAM SEDIAAN GEL ANTIOKSIDAN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Plants papaya is one of a field that is possessing antioxidant activity. One part of papaya plants that possessing antioxidant activity is papaya seeds because its contains flavonoids. The research aims to understand antioxidant activity preparation gel extract papaya seeds (Carica papaya L.) The result showed that ethyl acetate of papaya seeds extract (Carica papaya L.) had the strongest antioxidant activity which is 64,611 µg/mL in the DPPH Assay, 2,48mmolTrolox/g DW TEAC Assay, 11116,67 µmol FeSO4/g DW in the FRAP Assay, 1318,73 µmol α-Tocopherol/g DW in the Superoxide Anion Radical-Scavenging Activity Assay, 73,38 µg Vc/mg DW in the Hydrogen Peroxide Radical-Scavenging Activiy Assay and0.0944 µg/mL in the Hydroxyl Radical-Scavenging Activity Assay.And then-butanol fraction of papaya seeds extract (Carica papaya L.) had the second strongest anrtioxidant activity which is109,30 µg/mL in the DPPH Assay, 4,75 mmolTrolox/g DW in the TEAC Assay,1365.86 µmol α-Tocopherol/g DW in the Superoxide Anion Radical-Scavenging Activity Assay, 79.24 µg Vc/mg DW in the Hydrogen Peroxide Radical-Scavenging Activiy Assay and 0.2101in the Hydroxyl Radical-Scavenging Activity Assay.Content of papaya seeds that have an antioxidant activity are alkaloids, phenolics, flavonoids, vitamin C, oleic acid and α-tocopherol. The extrct is made in the form of gel by using HPMC E4M and karbopol as gelling agent, because it’s easy to use and easy to wash with water and the presence of polar compounds. A combination of 0,2-0,6% HPMC E4M and 0,1-0,5% karbopol 940 bring out a clear gel, and such a good ability to release drugs may increase the bioavailability of its active substance. With this combination of gelling agent, will produce a good antioxidant activity in formula 2. Keywords: antioxidant activity, papaya seeds extract, gel

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antioxidant activity, papaya seeds extract, gel
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	17 Mar 2022 07:53
Last Modified:	17 Mar 2022 07:53
URI:	http://repo.setiabudi.ac.id/id/eprint/4605

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