Ayu, Nabela Dwi Kusuma (2021) PENGARUH KONSENTRASI GELLING AGENT HPMC K4M DAN KARBOPOL 941 TERHADAP KARAKTERISASI SIFAT FISIK SEDIAAN NANOGEL ALLANTOIN. Skripsi thesis, Universitas Setia Budi.
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Abstract
Comfrey plant (Symphytum officinale L.) contains namely allantoin which has activity of accelerating wound healing process. However, Allantoins are unstable and degraded with orally administration. Therefore, enhancement of allantoin can be inteded to incorporate into nanogel formulation to increase the value of allantoin release. The aim of this study was to incorporate allantoin into nanogel HPMC K4M and Carbopol 941 which can affect the physical properties. Allantoin nanogel was prepared using an ionic gelation method. Consentration of HPMC K4M : Carbopol 941, namely F1 (2%:2%); F2 (3%:1%) and F3 (3,5%:0,5%). The characterization of nanogel includes nanoparticle size and zeta potential then gel includes viscosity, adhesion, spreadability, and stability. Data were analyzed statistically using one-way ANOVA followed by the T-test. The resulted display that average of allantoin nanoparticles 167±4,64 nm and the zeta potential value 34±1,27 mV. The addition of HPMC K4M and Carbopol 941 concentrations affected increase if the viscosity and adhesion and reduce the value of the spreadability. Optimized formula comprising 2% HPMC K4M : 2% Carbopol 941 had the viscosity value of 300±21,79 dPa’s, adhesion of 18,84±0,12 seconds and spreadability of 4,15±0,16 cm. The freeze thaw stability test showed that the preparation remained stable during the storage process. Keywords: Allantoin, ionic gelation, Chitosan, TPP, HPMC K4M, Karbopol 941
| Item Type: | Thesis (Skripsi) |
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| Uncontrolled Keywords: | Allantoin, ionic gelation, Chitosan, TPP, HPMC K4M, Karbopol 941 |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 13 Jun 2022 06:55 |
| Last Modified: | 13 Jun 2022 06:55 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/4854 |
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