UJI AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK ETANOL KULIT BUAH ALPUKAT (Persea americana Mill.) PADA MENCIT PUTIH JANTAN YANG DIINDUKSI ALOKSAN

Sari, Dwi Novita (2021) UJI AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK ETANOL KULIT BUAH ALPUKAT (Persea americana Mill.) PADA MENCIT PUTIH JANTAN YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Diabetes mellitus is a chronic disease and usually people will get tired of using synthetic drugs, therefore the use of natural ingredients can suppress fewer side effects. Avocado peel has flavonoid compounds, alkaloids, tannins, saponins, carotenoids, total phenolics and anthocyanins. This study aims to determine whether avocado peel can be used to treat hyperglycemia and an effective dose for lowering blood glucose levels. The extraction method is maceration with 70% ethanol. Methods of measuring blood glucose levels with a glucometer and Glucose strip DR. The test animals consisted of 25 mice which were divided into 5 treatment groups, namely negative control CMC 0.5%, positive Glibenclamide 5 mg/kgBW and ethanol extract of avocado skin with a dose variation of 4.9 mg/20g BW mice, 9.8 mg/20g BW in mice and 19.6 mg/20g BW in mice. Data analysis used One Way ANOVA statistical analysis. The results showed that avocado peel extract can reduce blood glucose levels. The most effective dose of avocado peel extract was 19.6 mg/20g BW, mice did not show a significant difference with the positive control. Keywords: avocado fruit peel (Persea Americana Mill.), alloxan, glibenclamide, antihyperglycemic.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	avocado fruit peel (Persea Americana Mill.), alloxan, glibenclamide, antihyperglycemic.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	21 Jul 2022 03:58
Last Modified:	21 Jul 2022 03:58
URI:	http://repo.setiabudi.ac.id/id/eprint/4959

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