UJI MUTU FISIK DAN EFEKTIVITAS ANTIOKSIDAN SEDIAAN KRIM EKSTRAK ETANOL BUAH PEPAYA (Carica papaya L.) DENGAN KOMBINASI TWEEN 80 DAN SPAN 60 TERHADAP DPPH

Restu M, Kinanthi (2021) UJI MUTU FISIK DAN EFEKTIVITAS ANTIOKSIDAN SEDIAAN KRIM EKSTRAK ETANOL BUAH PEPAYA (Carica papaya L.) DENGAN KOMBINASI TWEEN 80 DAN SPAN 60 TERHADAP DPPH. Skripsi thesis, Universitas Setia Budi.

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Abstract

Papaya fruit (Carica papaya L.) contains flavonoids, phenolics, tannins, and vitamin C. Flavonoid compounds and vitamin C have antioxidant activity, so they can eliminate cell destroying chains. Premature aging can be avoided from compounds that have antioxidant activity. This study aims to determine the effect of the combination of tween 80 and span 60 on the preparation of papaya fruit ethanol extract cream on antioxidant activity. The ethanol extract of papaya fruit was obtained by maceration with 96% ethanol. The making of papaya fruit ethanol extract cream was divided into 3 formulas. F1 which contains a combination of tween 80 0.25 grams and span 60 9.75 grams. F2 contains a combination of tween 80 1 gram and span 60 9 grams. F3 contains tween 80 2 grams and span 60 8 grams. The antioxidant activity will be determined by the DPPH method and the calculation of the IC50 value. The cream preparations will be tested for physical quality including organoleptic tests, homogeneity, pH, spreadability, adhesion, viscosity, and stability of the cycling test method. This study found that the ethanol extract of papaya fruit can be made into cream preparations with good physical quality and activity as an antioxidant with an IC50 value of 43.907 ppm so that cream preparations could be made. Antioxidant activity test on cream preparations of papaya fruit ethanol extract concluded that F2 had very strong antioxidant activity, followed by F3 and F1. The values obtained by F2, F3 and F1 were 36.269 ppm, 36,768 ppm and 49.768 ppm, respectively. Keywords: antioxidant, papaya fruit, free radicals, span 60, tween 80, DPP

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antioxidant, papaya fruit, free radicals, span 60, tween 80, DPP
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	21 Jul 2022 04:00
Last Modified:	21 Jul 2022 04:00
URI:	http://repo.setiabudi.ac.id/id/eprint/4991

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