FORMULASI DAN OPTIMASI SEDIAAN ORALLY DISSOLVING FILM DIMENHIDRINAT DENGAN KOMBINASI HPMC K100M DAN MALTODEKSTRIN DENGAN METODE SIMPLEX LATTICE DESIGN

Lestari, Mira Rizki (2021) FORMULASI DAN OPTIMASI SEDIAAN ORALLY DISSOLVING FILM DIMENHIDRINAT DENGAN KOMBINASI HPMC K100M DAN MALTODEKSTRIN DENGAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Orally Dissolving Film or ODF is a new dosage form that dissolves or disintegrates more rapidly on the tongue or buccal cavity than conventional dosage forms. HPMC 2-20% and maltodextrin 2-10% have a function as a film former. This study aims to determine the effect of the concentration of HPMC K100M polymer and maltodextrin on organoleptic, disintegration time, dissolution, hydration study, taste acceptability and to determine the optimum proportion of HPMC K100M polymer and maltodextrin using a simplex lattice design. This study used eight formulas designed with the method simplex lattice design. The formula obtained is a variation of the composition of HPMC K100M and maltodextrin. ODF is made by method solvent casting. The predetermined formula was tested for organoleptic, thickness, folding endurance, content uniformity, pH, disintegration time, dissolution, hydration study, taste acceptability. The optimum formula was obtained by entering the critical parameter data of folding endurance, Q45, and DE45 in the expert design. Verification of the optimum formula was analyzed usingstatistical one sample T-test. The results showed that the eight variations of the polymer combination of HPMC K100M dan maltdextrin orally dissolving film dimenhydrinate resulted in good physical quality. HPMC K100M and maltodextrin affect disintegration time, folding endurance, Q45 and DE45. The combination of HPMC K100M polymer 17.0093 % (1.70094 mg) and maltodextrin 2.99072% (0.299 mg) resulted in the optimum formula for orally dissolving film dimenhydrinate with the best physical quality. Keywords: HPMC K100M, maltodextrin, sedian orally dissolving film, simplex lattice design

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	HPMC K100M, maltodextrin, sedian orally dissolving film, simplex lattice design
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	29 Jul 2022 07:46
Last Modified:	29 Jul 2022 07:46
URI:	http://repo.setiabudi.ac.id/id/eprint/5008

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