FORMULASI MASKER GEL PEEL-OFF EKSTRAK DAUN PEPAYA (Carica papaya L.) DENGAN VARIASI KONSENTRASI PVA DAN HPMC SERTA UJI TERHADAP BAKTERI PENYEBAB JERAWAT Staphylococcus epidermidis

Santy, Octaria (2021) FORMULASI MASKER GEL PEEL-OFF EKSTRAK DAUN PEPAYA (Carica papaya L.) DENGAN VARIASI KONSENTRASI PVA DAN HPMC SERTA UJI TERHADAP BAKTERI PENYEBAB JERAWAT Staphylococcus epidermidis. Skripsi thesis, Universitas Setia Budi.

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Abstract

Acne can be caused due to inflammation by the bacterium Staphylococcus epidermidis. Papaya leaf extract contains alkaloids and flavonoid compounds that act as antibacterial, can be formulated into a peel-off gel mask preparation. This study aims to determine the effect of variation and the best concentration of polyvinyl alcohol (PVA) and hydroxypropyl methylcellulose (HPMC) on the physical quality of the preparation, stability and antibacterial activity tests against Staphylococcus epidermidis bacteria. Papaya leaves were extracted using the maceration method with 96% ethanol as solvent. The extract was then made into a peel-off gel mask preparation with varying concentrations of PVA and HPMC FI (12% : 1%), FII (10% : 2%), and FIII (8% : 3%). The physical quality of each formula was tested for organoleptic, pH, homogeneity, spreadability, adhesion, viscosity, drying time, stability and antibacterial activity against Staphylococcus epidermidis. The data were analyzed statistically using the One-way Analysis of variance (ANOVA). Variations in the concentration of PVA and HPMC were used affect the physical quality of the preparation in the form of a decrease in spreadability value, increased adhesion time, viscosity, drying time, and decreased antibacterial activity. FI (PVA 12% and HPMC 1%) is the best formula that has good physical quality, stability, and antibacterial activity based on physical quality tests with a dispersion value of 3-5 cm, adhesion of more than 1 second, viscosity values ranging from 50-1000 dPas, the drying time is 15-30 minutes and the value of antibacterial inhibition 14,67 ± 0,49 mm. Keywards : anti acne, HPMC, peel-off gel mask, PVA, Staphylococcus epidermidis

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	anti acne, HPMC, peel-off gel mask, PVA, Staphylococcus epidermidis
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	29 Jul 2022 07:47
Last Modified:	29 Jul 2022 07:47
URI:	http://repo.setiabudi.ac.id/id/eprint/5023

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