UJI AKTIVITAS DIURETIK EKSTRAK DAUN LEUNCA (Solanum nigrum L) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus)

Krismanita, Agatha Mellinia Laras (2022) UJI AKTIVITAS DIURETIK EKSTRAK DAUN LEUNCA (Solanum nigrum L) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus). Skripsi thesis, Universitas Setia Budi.

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Abstract

Diuretic is drug that can increase the rate formation of urine and has the function to inhibit reabsorb sodium and potassium ion in the body. Leunca leaves have a diuretic effect because they contain flavonoids anda saponins compounds. The purpose of this research is to know the class of compounds in leunca leaf extract, and to determine the activity of leunca as a diuretic against wistar male white rats (Rattus norvegicus) and get an effective dose from leunca leaf extract as a diuretic drug. This research used 96% ethanol extract with maceration method. The animals for test used 25 male white rats divided into 5 groups with negative control being given CMC-Na 0.5%, positive control being given furosemide 3.6 mg/kg BB, and three test groups given leunca leaf extract at a dose of 125 mg/kgBB; 250 mg/kgBB; 500 mg/kgBB. Rat were put in metabolic cages, time to voiding (onset), and urine volume at 1 until 6 hours continued to 24 hours and the determination of sodium and potassium levels using AAS (Atomic Absorption Spectrophotometry) was tested by statistics. The results of this research that leunca leaf extract contains flavonoid compounds, alkaloids, tannins, saponins and triterpenoids. Diuretic activity of leunca leaf extract at a dose of 250 mg/kgBB can provide an effective dose by increasing urine volume and affecting sodium potassium levels of male white rats. Keywords: leunca (Solanum nigrum L), diuretic, urine volume, sodium level, potassium level.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	leunca (Solanum nigrum L), diuretic, urine volume, sodium level, potassium level.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	29 Sep 2022 04:37
Last Modified:	29 Sep 2022 04:37
URI:	http://repo.setiabudi.ac.id/id/eprint/5243

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