FORMULASI GEL MULUT EKSTRAK KULIT NANAS (Ananas comosus (L)Merr) DENGAN VARIASI KONSENTRASI HEC SEBAGAI ANTIBAKTERI TERHADAP BAKTERI Streptococcus mutans ATCC 25175

Hastuti, Lilis Puji (2022) FORMULASI GEL MULUT EKSTRAK KULIT NANAS (Ananas comosus (L)Merr) DENGAN VARIASI KONSENTRASI HEC SEBAGAI ANTIBAKTERI TERHADAP BAKTERI Streptococcus mutans ATCC 25175. Skripsi thesis, Universitas Setia Budi.

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Abstract

Pineapple peel extract contains tannins, alkaloids, flavonoids, and saponins which have antibacterial properties. Skin extract developed in oral gel preparations for the prevention of dental caries due to the activity of Streptococcus mutans bacteria. This study aims to determine the effect of basic variations of HEC on physical quality, antibacterial activity against Streptococcus mutans ATCC 25175 , and determine the best oral gel formula with antibacterial activity. Pineapple peel extract was obtained by maceration using 96% ethanol. Pineapple peel extract with a concentration of 6.25% was made into three formulas with variations of HEC (Hydroxy Ethyl Cellulosa) 2.5%, 3%, and 3.5%. Evaluation of the physical quality of oral gel preparations included organoleptic, spreadability, pH, adhesion, viscosity, homogeneity, and stability of the cycling test preparation. Testing the antibacterial activity of pineapple (Ananas comosus (L) Merr) oral gel preparation against Streptococcus mutans ATCC 25175 using the well method. Analysis of qualitative and quantitative data obtained using Microsoft Excel and SPSS version 24. Variations in the concentration of HEC in the oral gel preparation of pineapple peel extract affect the viscosity, dispersion, and adhesion of the preparation. The oral gel preparation with a concentration of 2.5% HEC was the best formula in this study which had the best physical quality and the most active antibacterial activity with an inhibitory diameter of 11.55 mm which was classified as strong. Keywords: Pineapple peel, Streptococcus mutans, mouth gel, HEC

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Pineapple peel, Streptococcus mutans, mouth gel, HEC
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	10 Oct 2022 07:30
Last Modified:	10 Oct 2022 07:30
URI:	http://repo.setiabudi.ac.id/id/eprint/5344

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