FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI Streptococcus mutans ATCC 25175 DARI SEDIAAN OBAT KUMUR EKSTRAK ETANOL BUNGA CENGKEH (Syzygium aromaticum L. Merr.)

Ananta, Maulidha Yuniza (2022) FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI Streptococcus mutans ATCC 25175 DARI SEDIAAN OBAT KUMUR EKSTRAK ETANOL BUNGA CENGKEH (Syzygium aromaticum L. Merr.). Skripsi thesis, Universitas Setia Budi.

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Abstract

Mouthwash is a liquid preparation with a good taste as an oral cleanser and helped kill or reduce bad breath. Many traditional plants had antibacterial activity, one of which is the clove flower. This study aimed to test the antibacterial activities against Streptococcus mutants bacteria form clove flower extract mouthwash preparations. The extract was obtained using the maceration method with 96% ethanol as solvent. The manufacture of mouthwash preparations used variations in the concentration of extracts 2.5%; 5%; and 7.5%. Physical quality and stability testing used organoleptic test parameters, homogeneity, pH, and viscosity. The result of the data were statistically tested using the Paired Samples T-Test. Antibacterial activities test using paper disc diffusion method. The result of the data were statistically tested using One Way Anova and Tukey follow-up test. The results obtained showed that the formulation of mouthwash clove preparations had good physical quality and stability, except that the pH of the preparations with concentrations of 5% and 7,5% did not meet the requirements. The preparation of clove flower extract mouthwash had the potential to be antibacterial. Mouthwash formulation with a concentration of 2.5% resulted in an inhibition zone of 8.00 ± 0.50 mm, 5% by 9.13 ± 0.61 mm, 7.5% by 11.60 ± 0.75 mm, K(+) is 12.57 ± 1.29 mm, and K(-) of 0.00 mm. The formulation of mouthwash preparation with an extract concentration of 7.5% had the most effective activity. Key words : Mouthwash, clove flower, Straptococcus mutans, disc diffusion.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Mouthwash, clove flower, Straptococcus mutans, disc diffusion.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	10 Oct 2022 07:31
Last Modified:	10 Oct 2022 07:31
URI:	http://repo.setiabudi.ac.id/id/eprint/5359

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