FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN KRIM EKSTRAK ETANOL DAUN KELAKAI (Stenochlaena palustris (Burm. F) Bedd.) MENGGUNAKAN METODE DPPH

Marlinandy, Efrim (2022) FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN KRIM EKSTRAK ETANOL DAUN KELAKAI (Stenochlaena palustris (Burm. F) Bedd.) MENGGUNAKAN METODE DPPH. Skripsi thesis, Universitas Setia Budi.

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Abstract

Ethanolic extract of Kelakai leaves (Stenochlaena palustris (Burm. F) Bedd) contains antioxidant compounds. To facilitate its use, the extract is formulated into a cream preparation. The aims of this study were to determine whether the extract could be made into a cream preparation that had good physical quality and stability, to determine its antioxidant activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) and to determine the concentration that gave the strongest antioxidant activity. Kelakai leaves were extracted by maceration method using 70% ethanol solvent and cream preparations were made using various extract concentrations of 23 ; 26 ; 29%. The resulting cream preparations were tested for physical quality including organoleptic test, homogeneity, emulsion type, pH test, adhesion test, spreadability test, viscosity and cycling test. The antioxidant activity of cream preparations was analyzed by the DPPH method. The results of several tests that have been carried out were analyzed using the SPSS program. The results of antioxidant activity test Kelakai leaves had an IC50 value of 55.50 ppm extract. The extract was made into a cream preparation with good physical quality on organoleptic tests, homogeneity, emulsion type, pH, viscosity, and adhesion. Cream preparations were stable on organoleptic, emulsion type, and viscosity tests. The IC50 values at F0, FI, FII, and FIII are 4810.13; 149.64; 122.87; and 107.54 ppm. The formula that gave the strongest antioxidant activity was 29% extract concentration. Keywords : 70% ethanol extract, Stenochlaena palustris (Burm. F) Bedd, cream, antioxidant activity, DPPH.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	70% ethanol extract, Stenochlaena palustris (Burm. F) Bedd, cream, antioxidant activity, DPPH.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 02:57
Last Modified:	30 Nov 2022 02:57
URI:	http://repo.setiabudi.ac.id/id/eprint/5489

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