UJI AKTIVITAS ANTIOKSIDAN SEDIAAN KRIM EKSTRAK DAUN SIRSAK (Annona Muricata L.) TERHADAP DPPH (1,1-Diphenyl-2- Picrylhydrazil)

Wati, Ni Putu Mega Krisna (2022) UJI AKTIVITAS ANTIOKSIDAN SEDIAAN KRIM EKSTRAK DAUN SIRSAK (Annona Muricata L.) TERHADAP DPPH (1,1-Diphenyl-2- Picrylhydrazil). Skripsi thesis, Universitas Setia Budi.

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Abstract

Soursop leaf (Annona muricata L.) is a plant that has anti-aging benefits because it contains flavonoid compounds that can act as antioxidants. Previous research on the antioxidant performance of 96% ethanol extract of soursop leaves was 79.320 ppm and included in the strong category. The purpose of this study was to determine the presence of antioxidant activity and the physical quality of soursop leaf extract cream preparations. Extraction was carried out by maceration method using 96% ethanol. Soursop leaf extract is then formulated into 3 cream formulations. Cream preparations were made using various concentrations of cetyl alcohol in formulas I, II and III (0.075%, 0.1% and 0.12%). The cream preparations were tested for physical quality including organoleptic, homogeneity, cream type, pH, dispersibility and adhesion, as well as antioxidant activity tests for soursop leaf extract cream preparations. The data were processed with One Way ANOVA statistics and continued with Dunnet and Post Hoc Turkey tests. Soursop leaf extract obtained as much as 62 grams. Phytochemical test results showed that soursop leaf extract contains alkaloids, flavonoids, saponins and tannins. The preparation of soursop leaf extract cream showed that FI, FII and FIII had met the requirements for the physical quality of the cream, namely organoleptic, homogeneity, cream type, pH, spreadability and adhesion. Antioxidant activity was determined by the DPPH method which has the principle of decreasing the absorbance value which is proportional to the increase in the concentration of antioxidant compounds expressed in IC50. The IC50 results obtained from soursop leaf extract (Annona muricata L.) are 71.57 ppm, vitamin C is 12.75 ppm and in cream formula I is 174.06 ppm, formula II is 152.11 ppm, and formula III is 145 ,46 ppm. Soursop leaf extract contains strong antioxidant activity, vitamin C is very strong, Formula I and II contain weak antioxidant activity, while Formula III contains moderate antioxidant activity. Formula III with 0.12% cetyl alcohol concentration variation is the best cream formula with the lowest IC50, so the antioxidant activity is high. Keywords: Antioxidants, Soursop Leaf (Annona muricata L.), DPPH, Physical Quality of Cream

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Antioxidants, Soursop Leaf (Annona muricata L.), DPPH, Physical Quality of Cream
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 04:18
Last Modified:	30 Nov 2022 04:18
URI:	http://repo.setiabudi.ac.id/id/eprint/5573

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