PENGARUH VARIASI KONSENTRASI HPMC TERHADAP MUTU FISIK SEDIAAN EMULGEL EKSTRAK ETANOL DAUN CEMPEDAK (Artocarpus integer (Thunb.) Merr.) SEBAGAI TABIR SURYA SECARA IN VITRO

Saputra, Rama Novianur (2022) PENGARUH VARIASI KONSENTRASI HPMC TERHADAP MUTU FISIK SEDIAAN EMULGEL EKSTRAK ETANOL DAUN CEMPEDAK (Artocarpus integer (Thunb.) Merr.) SEBAGAI TABIR SURYA SECARA IN VITRO. Skripsi thesis, Universitas Setia Budi.

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Abstract

Free radicals or sun exposure cause pigmentation, erythema, and degenerative diseases. Sunscreen can prevent sun exposure. The flavonoid compounds in cempedak leaves have natural sunscreen activity. The purpose of this study was to determine the effect of HPMC variations on emulgel preparations of cempedak leaf ethanol extract on physical quality and stability including viscosity and dispersion, as well as in vitro sunscreen activity. The extract was obtained from the maceration process using 96% ethanol. Emulgel is formulated using 4% extract and 3.5% gelling agent HPMC variation; 4.5%; and 5.5%. Emulgel test parameters include organoleptic test, homogeneity, viscosity, pH, dispersion, adhesion, stability test, cycling test, and sunscreen activity test. Emulgel was carried out in vitro by measuring the value of Sun Protection Factor (SPF) using UV Spectrophotometry. Analysis of the results using SPSS with ANOVA test and Dunnet T3 Post Hoc test. The results showed that the emulgel formulation of cempedak leaf ethanol extract had good physical quality and stability as well as sunscreen activity. Formula I with extract concentration of 4% HPMC 3.5% became the best formula with SPF value of 13.9 (maximum protection), SPF value of formula II 12.796 and formula III 11.817 with maximum protection category. Keywords: Artocarpus integer (Thunb.) Merr, Emulgel, SPF, Sunscreen.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Artocarpus integer (Thunb.) Merr, Emulgel, SPF, Sunscreen.
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	30 Nov 2022 04:15
Last Modified:	30 Nov 2022 04:15
URI:	http://repo.setiabudi.ac.id/id/eprint/5592

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