PERBEDAAN HASIL PEMERIKSAAN ENZIM TRANSAMINASE PADA PASIEN MDR-TB DALAM TERAPI DI RSUD Dr MOEWARDI SURAKARTA

Fatharani, Nuritha (2017) PERBEDAAN HASIL PEMERIKSAAN ENZIM TRANSAMINASE PADA PASIEN MDR-TB DALAM TERAPI DI RSUD Dr MOEWARDI SURAKARTA. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Multi-drug-resistant Tuberculosis (MDR-TB) is a type of tuberculosis which is resistant to treatments with rifampin and isoniazid with or without other types of antituberculosis drugs (ATD). Medicines used in MDR-TB therapy are identified causing hepatotoxic signalized with increased transaminase enzyme levels. This study aims at investigating the differences of transaminase enzyme examination results of patients with multi-drug-resistant tuberculosis (MDR-TB) under therapies (0, 6, 12 months). This research belongs to observational analytical study with cross-sectional method. Secondary data were 51 samples of patients with MDR-TB. This study was conducted from February to March 2017 in Regional Public Hospital (RSUD) of Dr. Moewardi. Data were processed using SPS with Kolmogorov Smirnov test to observe tha data normality, repeated ANOVA with significance level of p<0.05, and paired sample Ttest with p<0.05 and confidence interval of 95%. The results conclude that there is not any significant differences of transaminase enzyme examination results of patients with MDR-TB under 0, 6, and 12 months of therapies (p=0.060 and p=0.101). Significant differences appear to happen on serum glutamic oxaloacetic transaminase (SGOT) therapy in 0 and 6 months (p=0.017), SGOT therapy in 0 and 12 months (p=0.047) and siamane glutamate pyruvate transaminase (SGPT) therapy in 0 and 6 months (p=0.033). Keywords: MDR-TB, SGOT, SGPT, therapy period, RSDM

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Keywords: MDR-TB, SGOT, SGPT, therapy period, RSDM
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Ilmu Kesehatan > Prodi D4 Analis Kesehatan
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 02:50
Last Modified: 23 Feb 2019 02:50
URI: http://repo.setiabudi.ac.id/id/eprint/562

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