Suyit, Zhicizha Estara (2022) FORMULASI SEDIAAN PASTA GIGI GEL EKSTRAK BUAH APEL MANALAGI (Pyrus malus var. sylvestris L) DENGAN VARIASI KONSENTRASI CMC-NA SEBAGAI ANTIBAKTERI TERHADAP Streptococcus mutans ATCC 25175. Skripsi thesis, Universitas Setia Budi.
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Abstract
Dental caries can be experienced at various ages which is marked by the appearance of white spots on the tooth surface by S. mutans bacteria. Manalagi apples contain compounds that are effective as antibacterial, namely polyphenols, saponins, alkaloids, tannins and flavonoids. Gel toothpaste formula with variations in CMC-Na of F1 (1.5%), F2 (2%), and F3 (2.5%). The purpose of this study was to determine the effect of variations in CMC-Na concentration on the physical quality and antibacterial activity of S. mutans in the Manalagi apple extract gel toothpaste. Manalagi apple simplicia was extracted using 70% ethanol. Manalagi apple extract 15% was formulated into 3 formulas F1, F2, and F3 with CMC-Na concentrations of 1.5, 2, and 2.5%, respectively. Toothpaste gel preparations were tested for physical quality for 21 days, stability test for 3 cycles and antibacterial activity test against S. mutans by disc diffusion method. Data were processed with Shapirowilk statistics, ANOVA and Krustal Wallis, followed by Paired t test and Wilcoxon The results showed that F1, F2, F3 affected the physical quality, among others, caused a decrease in the dispersion area but increased viscosity, pH and vice versa, as well as in the preparation of Manalagi apple extract gel toothpaste with various concentrations having antibacterial activity with inhibition zones 39 successively. ,8; 39.6 and 37.3 mm, and the best formula was F1. Keywords: S. mutans, CMC-Na, manalagi apple extract, gel toothpaste.
| Item Type: | Thesis (Skripsi) |
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| Uncontrolled Keywords: | S. mutans, CMC-Na, manalagi apple extract, gel toothpaste. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | Tifany Nur Arfiana |
| Date Deposited: | 30 Nov 2022 02:59 |
| Last Modified: | 30 Nov 2022 02:59 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/5652 |
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