NETWORK PHARMACOLOGY BUAH MENGKUDU (Morinda citrifolia L.) SEBAGAI ANTIHIPERTENSI

Rahmawati, Devi (2022) NETWORK PHARMACOLOGY BUAH MENGKUDU (Morinda citrifolia L.) SEBAGAI ANTIHIPERTENSI. Skripsi thesis, Universitas Setia Budi.

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Abstract

Hypertension is a non-communicable disease characterized by systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg. Noni fruit has been reported to have the ability to reduce high blood pressure. The purpose of this study was to determine the target protein that is predicted to be the target of noni fruit compounds as an antihypertensive agent and to determine the network pharmacology profile of noni fruit chemical compounds on hypertension target proteins. This study uses the network pharmacology method. Collection of data on the content of plant chemical compounds using KNApSAcK, IJAH Analytics, and research journals. The bioactivity of the compounds was obtained from PubChem. Target proteins involved in the pathophysiology of hypertension were identified using the KEGG pathway and research journals. The target protein was validated by gene name using UniProt. Protein-protein interactions using String. Target protein prediction from bioactive compounds using Swiss Target Prediction, SEA, and SuperPred. Network pharmacology visualization of protein-protein interactions and compound-protein interactions using Cytoscape. Network pharmacology visualization shows that the target proteins ACE2, EDN1, EDNRA, MME, and PRCP are predicted to be the working targets of noni fruit compounds as antihypertensives. The compounds kaempferol, quercetin, balanophonin, asperulosidic acid methyl ester, vomifoliol, and lirioresinol B interact to form a network pharmacology profile with predictive target proteins involved in the pathophysiology of hypertension. Keywords: hypertension, noni, network pharmacology, cytoscape

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	hypertension, noni, network pharmacology, cytoscape
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Apr 2023 03:00
Last Modified:	05 Apr 2023 03:00
URI:	http://repo.setiabudi.ac.id/id/eprint/5770

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