UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN JAMBU AIR (Syzygium aqueum (Burm.f) Alston) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI KARAGENIN

Waryaningsih, Diah Ayu (2022) UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN JAMBU AIR (Syzygium aqueum (Burm.f) Alston) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI KARAGENIN. Skripsi thesis, Universitas Setia Budi.

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Abstract

Water guava leaf is a plant that has several chemical compounds such as flavonoids, tannins, terpenoids, saponins, and alkaloids, where these compounds can be used as anti-inflammatory. Inflammation is an injury in the form of tissue damage that causes redness. This study aims to determine the anti-inflammatory activity and the most effective dose of water guava leaves in male white rats. The method used for extracting water guava leaves is maceration with 96% ethanol as solvent. The doses of water guava leaf extract to be given are 100 mg/kg weight, 200 mg/kg weight, and 400 mg/kg weight, with a positive control comparison of 0.9 mg/200gr weight sodium diclofenac rats orally, and a negative control CMC- Na 1%. Anti-inflammatory testing was carried out by subplantar formation of edema with 1% 0.05 ml carrageenan inducer. From the edema observation data, it is found that the percentage of edema and the percentage of edema inhibition will be xvnalysed with Shapiro-Wilk to see the distribution of the data and Levene to see the homogeneity of the data, then a one-way ANOVA test will be carried out and Post Hoc Tukey test. The result showed that the ethanol extract of water guava leaves had anti-inflammatory activity at a dose of 100 mg/kgBb with a percent inhibition of edema of 4,06%, a dose of 200 mg/kgBb of 15,80% , and a dose of 400 mg/kgBb had a higher percent inhibition of edema the effective is 41,81%. Keywords : anti-inflammatory, NSAID, water guava leaf extract, maceration, carrageenin

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	anti-inflammatory, NSAID, water guava leaf extract, maceration, carrageenin
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Apr 2023 02:57
Last Modified:	05 Apr 2023 02:57
URI:	http://repo.setiabudi.ac.id/id/eprint/5771

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