FORMULASI EMULGEL EKSTRAK ETANOL DAUN SIRSAK (Annona muricata Linn.) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP Staphylococcus aureus

Mileniawati, Agnes Nur (2022) FORMULASI EMULGEL EKSTRAK ETANOL DAUN SIRSAK (Annona muricata Linn.) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP Staphylococcus aureus. Skripsi thesis, Universitas Setia Budi.

	Text INTISARI ABSTRACT.pdf Download (31kB)
	Text COVER - BAB 1.pdf Download (804kB)
	Text BAB 2.pdf Restricted to Repository staff only Download (197kB) | Request a copy
	Text BAB 3.pdf Restricted to Repository staff only Download (208kB) | Request a copy
	Text BAB 4.pdf Restricted to Repository staff only Download (246kB) | Request a copy
	Text BAB 5.pdf Restricted to Repository staff only Download (25kB) | Request a copy
	Text LAMPIRAN.pdf Download (2MB)
	Text DAFTAR PUSTAKA.pdf Download (124kB)
	Text SURAT KETERANGAN_HasilTurnitin.pdf Download (22kB)
	Text Surat Publikasi_Agnes Nur Mileniawati_24185565A.pdf Download (499kB)

Abstract

Soursop leaves (Annona muricata Linn.) has antibacterial activity against Staphylococcus aureus because it contains alkaloids, flavonoids, terpenoids, saponins, and tannins so that potential as antibacterial. The addition of a gelling agent, namely carbopol 940, to the emulgel can have an effect on the physical quality and stability of the preparation. The research aims to determine emulgel preparations of ethanol extract of soursop leaves with various concentrations of the gelling agent carbopol 940 can produce physical quality that meets the requirements and is stable and can produce antibacterial activity against Staphylococcus aureus. This research was conducted by extracting soursop leaves by maceration method using 96% ethanol, then three emulgel formulas were made, namely FI, FII, and FIII, each containing gelling agent carbopol 940, successively 0,75; 1; and 1,25%. All formulas were tested for physical quality and stability including organoleptic, homogeneity, pH, spreadability, adhesion, viscosity, and type of emulsion emulgel. Test the antibacterial activity of the preparation emulgel is conducted by diffusion method of wells. All the data obtained were analyzed using the One-way ANOVA, Post Hoc, and Paired-Samples T Test method. The result showed that FI, FII, and FIII emulgel ethanol extract of soursop leaves with variations in the concentration of gelling agent carbopol 940 0,75; 1; and 1,25% affects produces physical quality that meets the requirements and is stable on organoleptic parameters, pH, viscosity, spreadability, and adhesion. The results also showed that variations in the concentration of carbopol 940 had antibacterial activity against Staphylococcus aureus with successive results of 14,08; 13,08; and 12,50 mm. Emulgel Formula I has the best physical quality, stability, and antibacterial activity. Key words : Annona muricata Linn., soursop leaves, antibacterial, Staphylococcus aureus, emulgel.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Annona muricata Linn., soursop leaves, antibacterial, Staphylococcus aureus, emulgel.
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	03 Jul 2023 04:29
Last Modified:	03 Jul 2023 04:29
URI:	http://repo.setiabudi.ac.id/id/eprint/5929

Actions (login required)

View Item