FORMULASI TABLET LEPAS LAMBAT KAPTOPRIL DENGAN KOMBINASI MATRIKS HIDROKSIPROPIL METIL CELLULOSA (HPMC) K15M DAN XANTHAN GUM

HIDAYAT, ARIF MARISA NUR (2016) FORMULASI TABLET LEPAS LAMBAT KAPTOPRIL DENGAN KOMBINASI MATRIKS HIDROKSIPROPIL METIL CELLULOSA (HPMC) K15M DAN XANTHAN GUM. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Captopril is a drug with a very short half-life (2-3 hours) are widely used in diseases of the system cardiovascular especially hypertension with the use of the frequency of multiple times a day, captopril formulated in sustained release form. The purpose of this study was to determine the effect of the combination xanthan gum and HPMC K15M the physical quality of granules, tablets, and drug release follows zero order. This study was made in five formulations include: comparison of HPMC K15M and xanthan gum (F1 = 0%: 100%, F2 = 25%: 75%, F3 = 50%: 50%, F4 = 75%: 25%, F5 = 100%:0%). Tablets made by wet granulation and printed with a tablet weight of 250 mg. The granules and tablets formed testing the physical properties of the granules and tablets, among others: the flow time, angle of repose, moisture content, weight uniformity, friability, tablet hardness, and dissolution. The test results obtained formula by using Matrix HPMC K15M with a concentration higher improved physical properties tablet captopril with hardness values higher, the fragility of the lower, while the matrix of xanthan gum at concentrations higher improve flow time of the granules, and in formula 2, formula 3, formula 4 and formula 5, generating captopril tablets release follows zero-order release kinetics. Keyword: captopril, sutained-release preparations, HPMC K15M, xanthan gum, granulation.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: captopril, sutained-release preparations, HPMC K15M, xanthan gum, granulation.
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: magdalena kartika ningsih
Date Deposited: 23 Feb 2019 02:59
Last Modified: 23 Feb 2019 02:59
URI: http://repo.setiabudi.ac.id/id/eprint/626

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