PENGARUH FORMULASI SEDIAAN TABLET LIQUISOLID NIFEDIPIN MENGGUNAKAN KOMBINASI TRANSCUTOL DAN LAKTOSA TERHADAP MUTU FISIK DAN DISOLUSI

Pradela, Niken (2024) PENGARUH FORMULASI SEDIAAN TABLET LIQUISOLID NIFEDIPIN MENGGUNAKAN KOMBINASI TRANSCUTOL DAN LAKTOSA TERHADAP MUTU FISIK DAN DISOLUSI. Skripsi thesis, Universitas Setia Budi.

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Abstract

Nifedipin merupakan obat yang memiliki kelarutan rendah dan permeabilitas tinggi. Upaya menaikkan disolusi dan memperbaiki bioavaibilitas nifedipin dilakukan dengan metode liquisolid. Tujuan penelitian ini untuk mengetahui pengaruh transcutol dan laktosa terhadap mutu fisik dan disolusi tablet liquisolid nifedipin, serta untuk mengetahui formula terbaik pada pembuatan tablet liquisolid nifedipin. Penelitian ini menggunakan nifedipin dengan bahan tambahan transcutol sebagai pelarut non-volatile dan laktosa sebagai carrier material menggunakan metode kempa langsung. Tablet dicetak dengan bobot kurang lebih 200 mg dengan variasi perbandingan formula. Formula 1 (20% transcutol : 80% laktosa), formula 2 (25% transcutol : 75% laktosa), formula 3 (30% transcutol : 70% laktosa), dan satu formula sebagai kontrol. Uji yang dilakukan yaitu uji fisik tablet dan disolusi. Data hasil penelitian dianalisis menggunakan Oneway ANOVA dan Turkey’s honest significant difference. Hasil uji tablet menggambarkan transcutol berpengaruh signifikan menurunkan kerapuhan, menaikkan kekerasan, waktu hancur, keseragaman kandungan, dan laju disolusi tablet, sedangkan laktosa tidak berpengaruh signifikan terhadap mutu fisik tablet, dan memberikan sedikit pengaruh signifikan pada uji granul. Formula yang baik dari seluruh uji mutu fisik, dan uji disolusi yaitu pada formula 2 dengan perbandingan (25% transcutol : 75% laktosa) dan formula 3 dengan perbandingan (30% transcutol : 70% laktosa). Nifedipine is a drug that has low solubility and high permeability. Efforts to increase dissolution and improve bioavailability of nifedipine were carried out with the liquisolid method. The purpose of this study was to determine the effect of transcutol and lactose on the physical quality and dissolution of nifedipine liquisolid tablets, and to determine the best formula for making nifedipine liquisolid tablets. This study used nifedipine with transcutol as a non-volatile solvent and lactose as a carrier material using the direct felting method. Tablets were molded with a weight of approximately 200 mg with various formula comparisons. Formula 1 (20% transcutol: 80% lactose), formula 2 (25% transcutol: 75% lactose), formula 3 (30% transcutol: 70% lactose), and one formula as control. The tests carried out were physical tablet and dissolution tests. The data were analyzed using Oneway ANOVA and Turkey's honest significant difference. The tablet test results illustrated that transcutol had a significant effect on reducing friability, increasing hardness, disintegration time, content uniformity, and dissolution rate of tablets, while lactose had no significant effect on the physical quality of tablets, and had a slight significant effect on the granule test. Good formulas from all physical quality tests, and dissolution tests are in formula 2 with a ratio (25% transcutol: 75% lactose) and formula 3 with a ratio (30% transcutol: 70% lactose).

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	liquisolid nifedipin, transcutol, laktosa, uji mutu fisik tablet, disolusi, actose, physical quality test, dissolution.
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	USB
Date Deposited:	26 Jun 2024 02:12
Last Modified:	26 Jun 2024 02:12
URI:	http://repo.setiabudi.ac.id/id/eprint/6268

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