UJI AKTIVITAS ANALGESIK ANTIPIRETIK EKSTRAK DAUN LEUNCA (Solanum nigrum L.) TERHADAP MENCIT JANTAN (Mus muscular)

Lodan, Anjelica Iriani (2024) UJI AKTIVITAS ANALGESIK ANTIPIRETIK EKSTRAK DAUN LEUNCA (Solanum nigrum L.) TERHADAP MENCIT JANTAN (Mus muscular). Skripsi thesis, Universitas Setia Budi.

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Abstract

ANJELICA IRIANI LODAN, 2024, UJI AKTIVITAS ANALGESIK ANTIPIRETIK EKSTRAK DAUN LEUNCA (Solanum nigrum L.) TERHADAP MENCIT JANTAN (Mus Muscular), SKRIPSI, FAKULTAS FARMASI, UNIVERSITAS SETIA BUDI, SURAKARTA. Nyeri merupakan perasaan sensorik yang tidak menyenangkan yang dapat diatasi dengan analgesik. Demam merupakan kenaikan suhu tubuh di atas rata – rata suhu normal yang dapat diatasi dengan antipiretik. Tujuan dari penelitian ini yaitu untuk mengetauhi aktivitas dan menentukan dosis efektif analgesik antipiretik ekstrak etanol daun leunca terhadap mencit jantan yang diinduksi dengan asam asetat 1% dan pepton10%. Penelitian ini dilakukan pengujian yaitu analgesik dan antipiretik dengan menggunakan 50 ekor mencit jantan putih swiss webster. Pengujian ini dibagi menjadi 5 kelompok perlakuan yaitu kontrol negatif (CMC Na 0,5% dosis 0,5 ml/20 gram BB mencit), kontrol positif (paracetamol), dan kelompok perlakuan ekstrak daun leunca (245 mg/kgBB mencit, 490 mg/kg BB mencit dan 980 mg/kg BB mencit). Mencit diinduksi pepton 10% dosis 0,01 ml/gr BB mencit secara subkutan dan asam asetat 1% dosis 0,2 ml/gr BB mencit secara intraperitoneal. Suhu tubuh diukur menggunakan thermometer digital melalui rektal, suhu diukur setiap 15 menit selama 90 menit setelah pemberian peroral. Nyeri dilihat ketika adanya geliat setiap 15 menit selama 90 menit setelah pemberian peroral. Data yang diperoleh selanjutnya dianalisis dengan menggunakan aplikasi SPSS dengan metode One Way ANOVA kemudian dilanjutkan uji Post Hoc LSD. Hasil penelitian menunjukan ekstrak daun leunca memiliki aktivitas sebagai analgesik dengan dosis efektif ekstrak daun leunca yaitu 490 mg/kg BB mencit. menunjukan ekstrak daun leunca memiliki aktivitas sebagai antipiretik dengan dosis efektif ekstrak daun leunca yaitu 245 mg/kg BB mencit. ANJELICA IRIANI LODAN, 2024, ANTIPIRETIC ANALGESIC ACTIVITY TEST OF LEUNCA LEAVES (Solanum nigrum L.) EXTRACT ON ANIMAL MENCITS (Mus muscular), FACULTY OF PHARMACY, SETIA BUDI UNIVERSITY, SURAKARTA. Pain is an unpleasant sensory feeling that can be managed with analgesics. Fever is an increase in body temperature above the average normal temperature that can be overcome with antipyretics. The purpose of this study was to determine the activity and determine the effective dose of antipyretic analgesic ethanol extract of leunca leaves against male mice induced with 1% acetic acid and 10% peptone. This research carried out analgesic and antipyretic tests using 50 white Swiss Webster males. This test was divided into 5 treatment groups, namely negative control (CMC Na 0.5% dose 0.5 ml/20 grams BW of mice), positive control (paracetamol), and leunca leaf extract treatment group (245 mg/ kgBW of mice, 490 mg/kg BW of mice and 980 mg/kg BW of mice). Mice were induced with 10% peptone at a dose of 0.01 ml/g of mouse body weight subcutaneously and 1% acetic acid at a dose of 0.2 ml/g of mouse body weight intraperitoneally. Body temperature is measured using a digital thermometer rectally, temperature is measured every 15 minutes for 90 minutes after oral administration. Pain is seen when there is squirming every 15 minutes for 90 minutes after oral administration. The data obtained was then explained using the SPSS application with the One Way ANOVA method then continued with the Post Hoc LSD test. The results of the research show that leunca leaf extract has activity as an analgesic with an effective dose of leunca leaf extract, namely 490 mg/kg body weight of mice. shows that leunca leaf extract has antipyretic activity with an effective dose of leunca leaf extract, namely 245 mg/kg BW of mice

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Daun leunca (Solanum nigrum), ekstrak etanol daun leunca, Analgesik, antipiretik. Leunca leaf (Solanum nigrum), Leunca leaf ethanol extract, Analgesic, antipyretic.
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	USB
Date Deposited:	01 Jul 2025 08:16
Last Modified:	01 Jul 2025 08:16
URI:	http://repo.setiabudi.ac.id/id/eprint/6618

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