FORMULASI SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) MINYAK ATSIRI BIJI PALA (Myristica fragrans Houtt)

Pareta, Douglas Natan (2016) FORMULASI SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) MINYAK ATSIRI BIJI PALA (Myristica fragrans Houtt). Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

Nutmeg essential oil is an essential oil derived from plants nutmeg (Myristica fragrans Houtt) are widely used as a cure bronchitis, antibacterial and antioxidant. Nutmeg essential oil has the disadvantage that stability is not good. This can be overcome by the application of nano technology with self-nanoemulsifying delivery system drug delivery system (SNEDDS) which will protect the essential oils of nutmeg and optimize the pharmacological activity. SNEDDS nutmeg oil is made by adding the oil phase, surfactant and co-surfactant. The oil phase, surfactant and co-surfactant in the formula SNEDDS nutmeg essential oil is determined based on the results of selection. Determining the best formula seen from the results of drug loading. The optimum formula was then characterized the time of emulsification and stability in gastric fluid and artificial intestinal, particle size distribution and zeta potential. SNEDDS nutmeg essential oil produces a homogeneous nanoemulsi. Transmittance value of 98.5% with a time of 1.39 minutes on aquadestilata emulsification, 1.96 minutes in artificial gastric solution, 1.25 minutes, the artificial gut and stable solution for 24 hours. The composition of the optimum formula SNEDDS nutmeg essential oil consisted of 1 mL VCO, 8 mL Tween 80, 1 mL of PEG 400 is capable of carrying 4 mL nutmeg essential oil and produced 19.1 nm diameter particle size and zeta potential measurement of -0, 2 mV and is stable in storage for 10 days. Keywords: Essential oils of nutmeg, nanoemulsi, SNEDDS, VCO, Tween 80, PEG 400 antioxidant.

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Keywords: Essential oils of nutmeg, nanoemulsi, SNEDDS, VCO, Tween 80, PEG 400 antioxidant.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 03:19
Last Modified: 22 Sep 2020 04:16
URI: http://repo.setiabudi.ac.id/id/eprint/665

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