ISOLASI SENYAWA AKTIF ANTIPLASMODIUM KULIT BATANG NANGKA (Artocarpus heterophyllus Lamk) DAN UJI AKTIVITAS ANTIMALARIA SECARA IN VITRO PADA PLASMODIUM STRAIN FCR3

Indriani, Nurul (2016) ISOLASI SENYAWA AKTIF ANTIPLASMODIUM KULIT BATANG NANGKA (Artocarpus heterophyllus Lamk) DAN UJI AKTIVITAS ANTIMALARIA SECARA IN VITRO PADA PLASMODIUM STRAIN FCR3. Tesis thesis, Universitas Setia Budi Surakarta.

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Abstract

The cortex of jackfruit (Artocarpus heterophyllus Lamk) is one of the natural materials has been used to treat malaria. Malaria is an infection caused by protozoa genus Plasmodium mediatated by Anopheles. This research aimed to determine jackfruit cortex active compounds and antimalarial activity from those compounds. Research method is fractionation of jackfruit cortex. In vitro test was applied to plasmodium strain FRC3 on some variant concentrations of cortex jackfruit fraction, those concentrations was 0 μg/ml, 0,1 μg/ml, 0,5 μg/ml, 1 μg/ml, 5 μg/ml, 10 μg/ml, 50 μg/ml, 100 μg/ml, 200 μg/ml and 400 μg/ml with three times replications. The result analyzed statistically used one way ANOVA with confidence interval level 95% (p = 0.05). The result showed that there are some active compounds were contained by [3-(2,3-epoxypropoxy)propyl]ethoxydimetyl; 3-pyrolidin-2-YL-proponic acid; 1,4-diaza-2,5-dioxobicyclo[4.3.0]; Heptadecanoid acid, ethyl ester (CAS) Ethyl n-heptadecanoate; Octadecanoic acid, butyl ester (CAS) Butyl stearate; which indicated has antimalarial activity. In vitro test showed, jackfruit concentration on 400 μg/mL has the highest performance to detain parasitemia up to 99,7%. Key Word : Artocarpus heterophyllus Lamk, Antimalarial, Plasmodium.

Item Type: Thesis (Tesis)
Uncontrolled Keywords: Key Word : Artocarpus heterophyllus Lamk, Antimalarial, Plasmodium.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S2 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 03:25
Last Modified: 22 Sep 2020 02:44
URI: http://repo.setiabudi.ac.id/id/eprint/712

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