Hidayah, Nur Atik (2016) UJI SITOTOKSIK FRAKSI n-HEKSANA DAN FRAKSI AIR KULIT BUAH PINANG (Areca catechu L.) TERHADAP SEL KANKER PAYUDARA T47D. Skripsi thesis, Universitas Setia Budi Surakarta.
![[img]](http://repo.setiabudi.ac.id/style/images/fileicons/text.png) |
Text
INTISARI.pdf Download (160kB) |
|
Text
FULL TEXT.pdf Download (5MB) |
Abstract
Cancer is one of the number two cause of death after cardiovascular diseases in the world. Breast cancer ranks first with a relative frequency of 18.6%. Research on cancer treatment are currently being directed at testing the potential of natural materials as a chemopreventive agent which aims to increase the sensitivity of cancer cells and reduce the side effects caused by chemotherapy agents. One natural ingredient that has been used and tested as a chemopreventive agent is a companion of the family Arecaceae is nut species. This study aims to determine the cytotoxic effect, IC50 and are the most effective of the fraction of n-hexane and water fraction betel nut skin on breast cancer cells T47D. The extraction process was with a nut rind maserasi method using ethanol 96%, followed by fractionation to obtain a fraction of n-hexane and water fraction. Test cytotoxic against cell T47D done with the test method MTT [3- (4,5dimetiltiazol-2-yl) -2-5-diphenyl tetrazolium bromide] with a concentration series (500, 250.125, 62.5, 31.2, 15 , 6; 7.8) μg / mL, and read the absorbance at λ ELISA reader at 595 nm. The parameters used are IC50. Results of research and analysis of independent t-test showed that the fraction of n-hexane and water fraction did not differ peel areca significant cytotoxic activity against T47D cells with IC50 value of 377,543 μg/mL and 380.851,935 μg/mL. Keywords: Peel areca nut (Areca catechu L.), T47D cells, cytotoxic.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Peel areca nut (Areca catechu L.), T47D cells, cytotoxic. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Farmasi > Prodi S1 Farmasi |
| Depositing User: | magdalena kartika ningsih |
| Date Deposited: | 23 Feb 2019 03:35 |
| Last Modified: | 23 Feb 2019 03:35 |
| URI: | http://repo.setiabudi.ac.id/id/eprint/779 |
Actions (login required)
 |
View Item |
