UJI AKTIVITAS ANTIBAKTERI SENYAWA ANALOG KURKUMIN DENGAN GUGUS FUNGSI 5´-bromo-2´-furanil TERHADAP BAKTERI RESISTEN DAN NON RESISTEN Staphylococcus aureus BESERTA MEKANISME KERJANYA

Fatwanda, Afra Azizah (2017) UJI AKTIVITAS ANTIBAKTERI SENYAWA ANALOG KURKUMIN DENGAN GUGUS FUNGSI 5´-bromo-2´-furanil TERHADAP BAKTERI RESISTEN DAN NON RESISTEN Staphylococcus aureus BESERTA MEKANISME KERJANYA. Skripsi thesis, Universitas Setia Budi Surakarta.

	Text INTISARI.pdf Download (156kB)
	Text skripsi full text afra.pdf Download (2MB)

Abstract

Curcumin has antibacterial activity that could modified the permeability of cell membrane. Structure modification of curcumin produced an analogue. The analogue could same mechanism as curcumin. The aim of this study was to find about antibacterial activity of 2,6-bis((5´-bromo-2´furanyl)methylene)cyclohexanone (compound D); 2,5-bis((5´-bromo-2´furanyl)metthylene)cyclopentanone (compound E); 1,5-bis(5´-bromo-2´-furanyl)1,4-pentadien-3-one (compound F) and mechanism. This study used 3 curcumin analogues that dissolved in acetone. The dilution method was used for screening antibacterial activity with 10.000 ppm initial concentration. The most active curcumin analogue were made 0x, 1x, and 2x of MBC concentration series. To find nucleic acid and protein that leaked was analyzed by UV-Vis at λ 260nm and 280nm and ion K+ and Na+ that leaked was analyzed using AAS. The results showed that all of the curcumin analogues had antibacterial activity. Compound F was the most active compound with 39,063 ppm of MBC to Staphylococcus aureus ATCC 25923 and 78,125 ppm to ciprofloxacin-resisted Staphylococcus aureus. The results of analyzed leaked cells was known that the most active compound still had same mechanism action with curcumin by changing the permeability of cells that confirmed by concentration increased of nucleic acid, protein, metal ion (K+ and Na+). Keyword: curcumin analogue, MBC, nucleic acid, protein, K+, Na+

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	curcumin analogue, MBC, nucleic acid, protein, K+, Na+
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Rohma Tri Wardani
Date Deposited:	23 Feb 2019 04:19
Last Modified:	23 Feb 2019 04:19
URI:	http://repo.setiabudi.ac.id/id/eprint/852

Actions (login required)

View Item