PENGARUH SISTEM NANOKOMPOSIT NA-MONTMORILLONIT TERPILAR KITOSAN BOBOT MOLEKUL SEDANG TERHADAP FOTOSTABILITAS NIFEDIPIN

Zulmi, Muhammad U'um (2017) PENGARUH SISTEM NANOKOMPOSIT NA-MONTMORILLONIT TERPILAR KITOSAN BOBOT MOLEKUL SEDANG TERHADAP FOTOSTABILITAS NIFEDIPIN. Skripsi thesis, Universitas Setia Budi Surakarta.

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Abstract

Nifedipine is easily degraded when exposes to an ultraviolet (uv) rays into nitrosofenylpyridine and nitrophenylpyridine derivatives. The nanocomposite of nifedipine in a medium molecular weight chitosan intercalated Na-montmorillonite (Nif-MMWC-Na-MMT) system is a nifedipine nano-encapsulation system in the basal spacing of Na-MMT. The objective of this research was to determine the effect of chitosan concentrationin the nanocomposite of Nif-MMWC-Na-MMT system on nifedipine photo-stability kinetics. Nifedipine and nanocomposites of Nif-MMWC-Na-MMT with chitosan variation of 2%, 3%, and 4%, respectively, exposed to uv rays at 254 nm. Each time interval of a sample was with drawn during 2 hours and analyzed by a high performance liquid chromatography. The determination of degradation kinetics using a fitting model of zero order, first order, and second order model it was depended on the goodness of fit i.e. coefficient of determination and root mean square error. Results were compared statistically with ANOVA using 95% confidence level. The nanocomposite system successfully enhanced the nifedipine photo-stability. Nifedipine lost 40% of its concentration mean while nanocomposite systems degraded 15-30% of nifedipine during the exposure. Nifedipine followed the first-order kinetics, although nanocomposite systems followed the second-order kinetics.The nanocomposite system altereds a kinetics order on the nifedipine degradation. Keywords: Nifedipine, Nanocomposite System, Kinetics and reaction order, Photo-stability.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Keywords: Nifedipine, Nanocomposite System, Kinetics and reaction order, Photo-stability.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi > Prodi S1 Farmasi
Depositing User: Herera Gadys USB
Date Deposited: 23 Feb 2019 04:26
Last Modified: 23 Feb 2019 04:26
URI: http://repo.setiabudi.ac.id/id/eprint/932

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