FORMULASI DAN UJI AKTIVITAS KRIM EKSTRAK ETANOL 96 % RIMPANG KUNYIT (Curcuma domestica Val.) SEBAGAI UV PROTECTION SECARA IN VITRO DAN IN SITU

Kurniawati, Yoana (2019) FORMULASI DAN UJI AKTIVITAS KRIM EKSTRAK ETANOL 96 % RIMPANG KUNYIT (Curcuma domestica Val.) SEBAGAI UV PROTECTION SECARA IN VITRO DAN IN SITU. Skripsi thesis, Universitas Setia Budi.

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Abstract

Radiation ultraviolet (UV) can penetrate the epidermis, damage the stratum corneum layers, and made skin irritation. Turmeric rhizoma (Curcuma domestica Val) contains curcumin compounds potentially preventing skin from UV radiation. This study aimed to determine the potential of turmeric rhizome ethanolic extract as UV light protection , to find optimal concentration of turmeric rhizome ethanol extract as UV light protection, the SPF value, and erythema protection ability of tumeric rhizome ethanolic extract cream. The concentration of turmeric rhizome ethanolic extract cream were 6%, 12%, and 18%. The effectiveness test of this cream was carried out by SPF test (Sun Protection Factor) in vitro and erythema test in situ. SPF test used UV-Vis spectrophotometry. The value of SPF were calculated by the Mansyur’s equation. Erythema test was carried out at rabbit back skin, smeared with turmeric rhizome ethanolic extract cream and irradiated with exottera UV B lamp for 24 hours. The result of SPF and erythema were statistically analyzed with one way anova. The results showed that the SPF value of concentrations cream 6%, 12%, and 18% were 13,248, 26,8023 and 34,3902 respectivelly. The concentration of 6% was included the maximum category, concentration of 12 % and 18% were included the ultra category. The results erythema test showed that all concentrations of the formula been able protected the skin of rabbit and erythema was not appear. Key words: radiation ultraviolet (UV), turmeric rhizome (Curcuma domestica Val.), SPF, erythema.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	radiation ultraviolet (UV), turmeric rhizome (Curcuma domestica Val.), SPF, erythema.
Subjects:	Q Science > QK Botany
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	16 Nov 2019 03:03
Last Modified:	16 Nov 2019 03:03
URI:	http://repo.setiabudi.ac.id/id/eprint/3904

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