UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAN FRAKSI AIR DAUN DELIMA (Punica granatum L) PADA MENCIT PUTIH JANTAN (Mus musculus) YANG DIINDUKSI Oleum Ricini

Lestari, Sri (2023) UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAN FRAKSI AIR DAUN DELIMA (Punica granatum L) PADA MENCIT PUTIH JANTAN (Mus musculus) YANG DIINDUKSI Oleum Ricini. Skripsi thesis, Universitas Setia Budi.

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Abstract

Diarrhea is a disease with typical symptoms, which are associated with increased stool mass, fluidity, and stool frequency. Currently, people still often use herbs as an alternative and diarrhea therapy. One of the many herbs that can be used as a medicine for diarrhea is pomegranate leaves (Punica granatum L). The tannin compounds contained in pomegranate leaves can reduce intestinal peristalsis so that it can relieve diarrhea. The research that was carried out had the aim of finding out the antidiarrheal effect of the water fraction and ethanol extract of pomegranate leaves on mice induced by oleum ricini. The research design used in this study was experimental using 30 mice and divided into 6 experimental groups. Group 1 was given 1% Na-CMC as a negative control, group 2 was given Loperamide HCl as a positive control, group 3 was given 8 mg/kgBW of pomegranate leaf extract, group 4 was given 16 mg/kgBW of pomegranate leaf extract, group 5 was given 32 mg/kgBW Pomegranate leaf extract, as well as group 6 were given 21.09 mg/kgBB water fraction of pomegranate leaves which was administered orally. The initial time of diarrhea was observed, the frequency of diarrhea, the weight of the stool, and also the duration of diarrhea which was observed for 6 hours. The results showed that the ethanol extract of pomegranate leaves had antidiarrheal activity. The effective dose of pomegranate leaf extract is a dose of 32 mg/kgBB. The water fraction of pomegranate leaves at a dose of 21.09 mg/kgBW can also provide antidiarrheal activity. Key words : Antidiarrhea, Pomegranate leaf, Oleum ricini, White mice, Loperamide HCL

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Antidiarrhea, Pomegranate leaf, Oleum ricini, White mice, Loperamide HCL
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Fakultas Farmasi > Prodi S1 Farmasi
Depositing User:	Tifany Nur Arfiana
Date Deposited:	05 Apr 2023 02:55
Last Modified:	05 Apr 2023 02:55
URI:	http://repo.setiabudi.ac.id/id/eprint/5821

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